#FLX-882PATHOGENIC
88%Similarity
Exhibits similar BRCT domain destabilization and loss of BACH1 interaction.
No Variant Report
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Structure View
COORD: X-104.32 Y+22.91 Z-0.12
RMSD: 0.42A | pLDDT: 92.4
RESIDUE: ASP234 (MUTANT)
Similar Known Variants
#FLX-129BENIGN
74%Similarity
Conservative substitution at adjacent residue with minimal structural impact.
#FLX-044PATHOGENIC
65%Similarity
Known to cause complete disruption of the protein core folding mechanism.
#FLX-912VUS
52%Similarity
Variant of uncertain significance with partial hydrophobic pocket exposure.
Wild Type vs. Variant Analysis
Wild Type Wild Type Variant Variant
| Parameter | Wild Type (Wild Type) | Variant (Variant) | Delta Value | Impact Assessment |
|---|---|---|---|---|
| H-Bond Density | 12 bonds / core | 8 bonds / core | -4.0 | SEVERE |
| Surface Exposure | 12.4 A2 | 45.8 A2 | +33.4 | HYDROPHOBIC SHIFT |
| Coulombic Energy | -142.1 kJ/mol | -98.4 kJ/mol | +43.7 | ELECTROSTATIC REPULSION |
| Backbone Strain | 0.24 kcal/mol | 2.88 kcal/mol | +2.64 | STERIC HINDRANCE |
| Solvation Energy | -45.2 kJ/mol | -48.1 kJ/mol | -2.9 | NEGLIGIBLE |